Great discussion, will have to play with the title tool more.
For similar reasons, my current go-to is designing the titles in Illustrator (a bit more text layout control than Photoshop), and then drop it into a Fusion animation to convert it to a ProRes4444 file that can be imported. In Fusion it was easy to create an expression for the Y coordinate that moves in even pixels. That's always the crux of animating an externally designed titles.
In Fusion you can put this expression into the Y axis of a transform node: 'time * 0.0005 - 0.5' if you're crawl was 2000 frames long as an example. And you would make your external graphic an even multiple of the frame count, either 2x, 3x, or 4x. Is that something that Mistika can do - express values as expression that reference other data?
Haven't had a chance yet to dive deeper into the Comp3D tool beyond applying alpha channels.
But being able to do all the animation and even some text inside Mistika speeds things up rather than switching between multiple apps.